Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_6
Snippet: Shortly after the discovery of HIV-1, then Secretary of Health and Human Services Margaret Heckler held a 1984 press conference in which she predicted that vaccine trials against HIV-1 would be possible within 2 years [9] . The first vaccine trial began in 1986 [10, 11] , and was followed by a series of attempts to develop an effective HIV-1 vaccine. Early vaccine studies focused on leveraging strategies that had been successful for other vaccine.....
Document: Shortly after the discovery of HIV-1, then Secretary of Health and Human Services Margaret Heckler held a 1984 press conference in which she predicted that vaccine trials against HIV-1 would be possible within 2 years [9] . The first vaccine trial began in 1986 [10, 11] , and was followed by a series of attempts to develop an effective HIV-1 vaccine. Early vaccine studies focused on leveraging strategies that had been successful for other vaccines including virus inactivation [12] [13] [14] and subunit immunogens [15] along with novel strategies such as recombinant viral constructs [11] . Although early subunit vaccine candidates were immunogenic [16] , none of the follow-up efficacy trials showed protection [17, 18] .
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