Selected article for: "detectable bacterial dna and molecular approach"
Author: Robinson, Lary A; Smith, Prudence; SenGupta, Dhruba J; Prentice, Jennifer L; Sandin, Ramon L
Title: Molecular analysis of sarcoidosis lymph nodes for microorganisms: a case–control study with clinical correlates
  • Document date: 2013_12_21
    • ID: 3unap1o9_110
    Snippet: • The entire group of sarcoidosis patients had significantly more detectable bacterial DNA than control patient lymph nodes. • Nevertheless, the molecular approach to bacterial detection has distinct limitations including possible false-positive results secondary to contaminated PCR reagents, the paraffin imbedding process, or post-embedding handling and processing of the paraffin block. Also the mere physical presence of the bacterial DNA in.....
    Document: • The entire group of sarcoidosis patients had significantly more detectable bacterial DNA than control patient lymph nodes. • Nevertheless, the molecular approach to bacterial detection has distinct limitations including possible false-positive results secondary to contaminated PCR reagents, the paraffin imbedding process, or post-embedding handling and processing of the paraffin block. Also the mere physical presence of the bacterial DNA in the lymph nodes does not prove that the disease is caused by the microorganism.

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