Author: Kammer, Andreas R.; van der Burg, Sjoerd H.; Grabscheid, Benno; Hunziker, Isabelle P.; Kwappenberg, Kitty M.C.; Reichen, Jürg; Melief, Cornelis J.M.; Cerny, Andreas
Title: Molecular Mimicry of Human Cytochrome P450 by Hepatitis C Virus at the Level of Cytotoxic T Cell Recognition Document date: 1999_7_19
ID: 1vabzhs5_5
Snippet: Study Population. 12 HLA-A2-positive healthy individuals and 10 HLA-A2-positive patients with chronic hepatitis C were studied. Samples of patients with chronic HCV infection were obtained at least 6 mo after diagnosis of HCV infection. All patients repeatedly tested positive for anti-HCV antibodies, and with one exception HCV RNA was detected by PCR. Most (8 out of 10) of the patients had not been treated with IFN-⣠before sample collection, a.....
Document: Study Population. 12 HLA-A2-positive healthy individuals and 10 HLA-A2-positive patients with chronic hepatitis C were studied. Samples of patients with chronic HCV infection were obtained at least 6 mo after diagnosis of HCV infection. All patients repeatedly tested positive for anti-HCV antibodies, and with one exception HCV RNA was detected by PCR. Most (8 out of 10) of the patients had not been treated with IFN-⣠before sample collection, and the other two patients finished an ineffective IFN-⣠treatment before sample collection. None of the HCV patients tested positive for autoimmune hepatitis serum markers. Patients and healthy blood donors were negative for antibodies to HIV and HBV and healthy donors were also negative for anti-HCV antibodies.
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