Author: Pipirou, Zoi; Powlesland, Alex S; Steffen, Imke; Pöhlmann, Stefan; Taylor, Maureen E; Drickamer, Kurt
Title: Mouse LSECtin as a model for a human Ebola virus receptor Document date: 2011_1_21
ID: 41i20yuy_18
Snippet: Based on the results in Figure 3 , showing that the simple GlcNAcβ1-2Man disaccharide competes at micromolar concentrations for binding of neoglycoprotein ligands to mouse LSECtin, as well as published work showing similar affinities of the human protein (Powlesland et al. 2008) , the disaccharide was tested for its ability to compete for binding of both receptors to the Ebola virus glycoprotein. The results demonstrate that the K I of the disac.....
Document: Based on the results in Figure 3 , showing that the simple GlcNAcβ1-2Man disaccharide competes at micromolar concentrations for binding of neoglycoprotein ligands to mouse LSECtin, as well as published work showing similar affinities of the human protein (Powlesland et al. 2008) , the disaccharide was tested for its ability to compete for binding of both receptors to the Ebola virus glycoprotein. The results demonstrate that the K I of the disaccharide is in the low micromolar range for both human and mouse receptors ( Figure 6 and Table II) . This result provides an important lead toward the development of high-affinity inhibitors of Ebola virus binding to sinusoidal endothelial cells as well as confirming that studies in the mouse will be relevant to humans as well.
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