Selected article for: "low micromolar range and micromolar range"
Author: Pipirou, Zoi; Powlesland, Alex S; Steffen, Imke; Pöhlmann, Stefan; Taylor, Maureen E; Drickamer, Kurt
Title: Mouse LSECtin as a model for a human Ebola virus receptor
  • Document date: 2011_1_21
    • ID: 41i20yuy_18
    Snippet: Based on the results in Figure 3 , showing that the simple GlcNAcβ1-2Man disaccharide competes at micromolar concentrations for binding of neoglycoprotein ligands to mouse LSECtin, as well as published work showing similar affinities of the human protein (Powlesland et al. 2008) , the disaccharide was tested for its ability to compete for binding of both receptors to the Ebola virus glycoprotein. The results demonstrate that the K I of the disac.....
    Document: Based on the results in Figure 3 , showing that the simple GlcNAcβ1-2Man disaccharide competes at micromolar concentrations for binding of neoglycoprotein ligands to mouse LSECtin, as well as published work showing similar affinities of the human protein (Powlesland et al. 2008) , the disaccharide was tested for its ability to compete for binding of both receptors to the Ebola virus glycoprotein. The results demonstrate that the K I of the disaccharide is in the low micromolar range for both human and mouse receptors ( Figure 6 and Table II) . This result provides an important lead toward the development of high-affinity inhibitors of Ebola virus binding to sinusoidal endothelial cells as well as confirming that studies in the mouse will be relevant to humans as well.

    Search related documents:
    Co phrase search for related documents
    • high affinity and important lead: 1
    • high affinity and LSECtin mouse: 1
    • high affinity and micromolar range: 1, 2, 3, 4, 5
    • high affinity and mouse human receptor: 1
    • human protein and important lead: 1
    • human protein and LSECtin mouse: 1, 2, 3, 4
    • human protein and micromolar concentration: 1
    • human protein and micromolar range: 1
    • human protein and mouse human receptor: 1, 2, 3, 4, 5
    • human protein and mouse study: 1, 2, 3, 4
    • human protein and receptor bind: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26
    • human protein and similar affinity: 1, 2, 3
    • human protein and sinusoidal endothelial cell: 1
    • important lead and micromolar range: 1
    • LSECtin mouse and mouse human receptor: 1, 2, 3
    • LSECtin mouse and neoglycoprotein ligand: 1
    • LSECtin mouse and receptor bind: 1
    • mouse human receptor and receptor bind: 1, 2
    • mouse study and receptor bind: 1, 2