Author: Pipirou, Zoi; Powlesland, Alex S; Steffen, Imke; Pöhlmann, Stefan; Taylor, Maureen E; Drickamer, Kurt
Title: Mouse LSECtin as a model for a human Ebola virus receptor Document date: 2011_1_21
ID: 41i20yuy_4
Snippet: In the studies described in this manuscript, biochemical characterization of mouse LSECtin is presented and close similarity in the sugar-binding properties of the two receptors, and their ability to interact with Ebola virus glycoprotein, is documented. In addition, it is demonstrated that the simple disaccharide GlcNAcβ1-2Man acts as an effective inhibitor of binding to the viral glycoprotein at micromolar concentrations......
Document: In the studies described in this manuscript, biochemical characterization of mouse LSECtin is presented and close similarity in the sugar-binding properties of the two receptors, and their ability to interact with Ebola virus glycoprotein, is documented. In addition, it is demonstrated that the simple disaccharide GlcNAcβ1-2Man acts as an effective inhibitor of binding to the viral glycoprotein at micromolar concentrations.
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