Author: Daniels, Keith A.; Devora, Gene; Lai, Wayne C.; O'Donnell, Carey L.; Bennett, Michael; Welsh, Raymond M.
Title: Murine Cytomegalovirus Is Regulated by a Discrete Subset of Natural Killer Cells Reactive with Monoclonal Antibody to Ly49h Document date: 2001_7_2
ID: 6n3dmle6_5
Snippet: We report here that an NK cell subset detected by the anti-Ly49 mAb 1F8 is essential for resistance to MCMV in C57BL/6 mice. This mAb was generated against Ly49H, a positively signaling Ly49 molecule (4) . It cross-reacts with Ly49C and I, which is detected by the 5E6 mAb. We report here that the 1F8 ϩ (C/I/H) 5E6 Ϫ (C/I) NK cell subset is essential for control of MCMV infection in C57BL/6 mice......
Document: We report here that an NK cell subset detected by the anti-Ly49 mAb 1F8 is essential for resistance to MCMV in C57BL/6 mice. This mAb was generated against Ly49H, a positively signaling Ly49 molecule (4) . It cross-reacts with Ly49C and I, which is detected by the 5E6 mAb. We report here that the 1F8 ϩ (C/I/H) 5E6 Ϫ (C/I) NK cell subset is essential for control of MCMV infection in C57BL/6 mice.
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