Author: Sadikot, Ruxana T.; Kolanjiyil, Arun V.; Kleinstreuer, Clement; Rubinstein, Israel
Title: Nanomedicine for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Document date: 2017_6_27
ID: 27gutwjd_17
Snippet: We have also tested the efficacy of TREM1 nanomicellar peptides in a model of LPSinduced sepsis and lung injury. TREM proteins are a family of immunoglobulin cell surface receptors expressed on myeloid cells. TREM1 was the first TREM identified, and blockade of TREM1 has been shown to improve survival in animal models of sepsis [33] . We have extensively studied the mechanisms by which TREM1 amplifies inflammation [30] [31] [32] [33] [34] . Previ.....
Document: We have also tested the efficacy of TREM1 nanomicellar peptides in a model of LPSinduced sepsis and lung injury. TREM proteins are a family of immunoglobulin cell surface receptors expressed on myeloid cells. TREM1 was the first TREM identified, and blockade of TREM1 has been shown to improve survival in animal models of sepsis [33] . We have extensively studied the mechanisms by which TREM1 amplifies inflammation [30] [31] [32] [33] [34] . Previous studies where TREM1 blockade was used therapeutically in models of sepsis and infection employed fusion proteins (soluble or extracellular components of TREM1) [23, 33] . These peptides are limited by their short half-life and therefore may not be practical for therapeutic purposes.
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