Author: Lundegaard, Claus; Lund, Ole; Kesmir, Can; Brunak, Søren; Nielsen, Morten
Title: Modeling the adaptive immune system: predictions and simulations Document date: 2007_12_15
ID: 5m269nzi_35
Snippet: Several groups have suggested prediction strategies to span these 'uncharacterized' regions of the HLA diversity (Brusic et al., 2002; Jojic et al., 2006; Nielsen et al., 2007; Zhu et al., 2006) . In different forms, all these methods exploit both peptide and primary HLA sequence as input information for training, aiming at simultaneously incorporating all HLA specificities. In a recent paper (Nielsen et al., 2007a) , it is successfully demonstra.....
Document: Several groups have suggested prediction strategies to span these 'uncharacterized' regions of the HLA diversity (Brusic et al., 2002; Jojic et al., 2006; Nielsen et al., 2007; Zhu et al., 2006) . In different forms, all these methods exploit both peptide and primary HLA sequence as input information for training, aiming at simultaneously incorporating all HLA specificities. In a recent paper (Nielsen et al., 2007a) , it is successfully demonstrated that such an approach can, to a very high degree, accurately characterize the binding motif for previously untested HLA-I molecules.
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