Selected article for: "diagnosis imaging modality and imaging modality"
Author: White, Crystal; Mortier, Jeremy; Verin, Ranieri; Maddox, Thomas; Goncalves, Rita; Sanchez-Masian, Daniel
Title: MRI findings of neuronal ceroid lipofuscinosis in a cat
  • Document date: 2018_3_5
    • ID: 0gzef0ae_17
    Snippet: Without knowledge of the causative genes involved in feline neuronal ceroid lipofuscinosis, definitive diagnosis is based on necropsy and histopathology results alone. MRI findings, combined with clinical signs, are the mainstay of the ante-mortem presumptive diagnosis. To support the use of this imaging modality in the ante-mortem diagnosis of feline neuronal ceroid lipofuscinosis, recruitment of more feline subjects with confirmed disease into .....
    Document: Without knowledge of the causative genes involved in feline neuronal ceroid lipofuscinosis, definitive diagnosis is based on necropsy and histopathology results alone. MRI findings, combined with clinical signs, are the mainstay of the ante-mortem presumptive diagnosis. To support the use of this imaging modality in the ante-mortem diagnosis of feline neuronal ceroid lipofuscinosis, recruitment of more feline subjects with confirmed disease into similar descriptive studies is essential in identifying distinct MRI findings within this population. Owing to the similarities in the MRI findings in this cat and those seen in humans and dogs it could be assumed that the imaging features would be the same or similar in other cases of feline neuronal ceroid lipofuscinosis. It would seem prudent, therefore, to consider neuronal ceroid lipofuscinosis within the list of differentials when faced with a cat showing similar neurological signs as our case, with evidence of generalised cerebral and cerebellar atrophy and diffuse T2W hyperintensity of the white matter on MRI.

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