Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_61
Snippet: The cyclin kinase inhibitor p21 is one of the molecules responsible for the antiapoptotic effects of senescence (21) . Overexpression of p21 increases the resistance to apoptosis of alveolar epithelial cells (22) , and the beneficial effects of lopinavir/ritonavir in VILI could represent the effects of the overexpression of this gene. In contrast, absence of p21 was associated with more severe lung injury and increased numbers of apoptotic cells,.....
Document: The cyclin kinase inhibitor p21 is one of the molecules responsible for the antiapoptotic effects of senescence (21) . Overexpression of p21 increases the resistance to apoptosis of alveolar epithelial cells (22) , and the beneficial effects of lopinavir/ritonavir in VILI could represent the effects of the overexpression of this gene. In contrast, absence of p21 was associated with more severe lung injury and increased numbers of apoptotic cells, as in previous reports (23) . Therefore, senescence can be viewed as part of an adaptive, protective mechanism.
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