Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation Document date: 2020_3_25
ID: ebwxryai_66
Snippet: Our findings have several implications regarding the pathogenesis of lung injury and its long-term consequences. First, the described senescent response may be beneficial in the acute phase, and could be activated using lopinavir. In a recent clinical trial in patients with lung disease caused by the SARS-CoV-2 coronavirus, lopinavir did not reduce mortality, but decreased the risk of ARDS development (33) . However, this strategy could worsen lu.....
Document: Our findings have several implications regarding the pathogenesis of lung injury and its long-term consequences. First, the described senescent response may be beneficial in the acute phase, and could be activated using lopinavir. In a recent clinical trial in patients with lung disease caused by the SARS-CoV-2 coronavirus, lopinavir did not reduce mortality, but decreased the risk of ARDS development (33) . However, this strategy could worsen lung repair and long-term outcomes.
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