Author: Yu, Xiaobo; Song, Lusheng; Petritis, Brianne; Bian, Xiaofang; Wang, Haoyu; Viloria, Jennifer; Park, Jin; Bui, Hoang; Li, Han; Wang, Jie; Liu, Lei; Yang, Liuhui; Duan, Hu; McMurray, David N.; Achkar, Jacqueline M.; Magee, Mitch; Qiu, Ji; LaBaer, Joshua
Title: Multiplexed Nucleic Acid Programmable Protein Arrays Document date: 2017_9_20
ID: 7t1o19kn_46
Snippet: NAPPA has been widely applied in protein-protein interactions, post-translational modifications (PTMs), antibody epitope mapping and discovery of (auto) antibody biomarkers for a variety of human diseases, including markers that are currently being used in the clinic for the detection of breast cancer [13, 14, 18, 20, 32, 36, [42] [43] [44] . Due to mRNA and protein diffusion during IVTT, the number of features per planar microscope slide has bee.....
Document: NAPPA has been widely applied in protein-protein interactions, post-translational modifications (PTMs), antibody epitope mapping and discovery of (auto) antibody biomarkers for a variety of human diseases, including markers that are currently being used in the clinic for the detection of breast cancer [13, 14, 18, 20, 32, 36, [42] [43] [44] . Due to mRNA and protein diffusion during IVTT, the number of features per planar microscope slide has been limited to ~2,300 to minimize cross-talk to neighboring spots. The feature density limit has thus required that multiple slides be used to study large proteomes.
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