Author: Sadikot, Ruxana T.; Kolanjiyil, Arun V.; Kleinstreuer, Clement; Rubinstein, Israel
Title: Nanomedicine for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome Document date: 2017_6_27
ID: 27gutwjd_10
Snippet: Nanomicelles stabilize peptides in active biological form (α-helix), which is preferred for ligand-receptor interactions, and prevents rapid peptide degradation in vivo, thereby prolonging bioactivity [25, 26] . Unlike surfactant micelles, a low critical micellar concentration (∼1 µM) of these nanoparticles prevents their disintegration upon dilution in biological fluids. Importantly, the PEG 2000 moiety of SSM confers steric hindrance in the.....
Document: Nanomicelles stabilize peptides in active biological form (α-helix), which is preferred for ligand-receptor interactions, and prevents rapid peptide degradation in vivo, thereby prolonging bioactivity [25, 26] . Unlike surfactant micelles, a low critical micellar concentration (∼1 µM) of these nanoparticles prevents their disintegration upon dilution in biological fluids. Importantly, the PEG 2000 moiety of SSM confers steric hindrance in the circulation, while their nanosize mitigates renal clearance and extravasation from intact microvessels. This, in turn, prolongs the circulation time of drug-loaded nanomicelles and promotes preferential extravasation from hyperpermeable lung microcirculation, the hallmark of ALI, into the injured lung.
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