Selected article for: "adaptive immunity and innate immunity"
Author: Chattopadhyay, Saborni; Chen, Jui-Yi; Chen, Hui-Wen; Hu, Che-Ming Jack
Title: Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation
  • Document date: 2017_6_9
    • ID: 7q2wkwrf_17
    Snippet: In particular, chitosan-based nanoparticles have been widely studied due to their biocompatibility, biodegradability, non-toxic nature and their ability to be easily modified into desired shapes and sizes [83] [84] [85] . More intriguing is the recent discovery of chitosan's immune potentiating mechanism via the DNA sensing cGAS-STING pathway [86] . The STING pathway is triggered in the host cells by many viral pathogens and plays a major role in.....
    Document: In particular, chitosan-based nanoparticles have been widely studied due to their biocompatibility, biodegradability, non-toxic nature and their ability to be easily modified into desired shapes and sizes [83] [84] [85] . More intriguing is the recent discovery of chitosan's immune potentiating mechanism via the DNA sensing cGAS-STING pathway [86] . The STING pathway is triggered in the host cells by many viral pathogens and plays a major role in both the innate and adaptive immunity [87] . Upon interaction with dendritic cells, chitosan induces type I interferons in a cGAS and STING-dependent fashion, mediating cellular maturation and the promotion of Th1 responses.

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