Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial Document date: 2019_5_18
ID: 19ueli6e_3
Snippet: Although animal models suggest a beneficial effect of rifamycins in the reduction of inflammation during pneumococcal infections, 13 data in humans are not available. Therefore, we hypothesized that non-lytic rifampicin compared with lytic b-lactam antibiotic treatment would attenuate the inflammatory response in patients with pneumococcal pneumonia, shortly after the start of their treatment......
Document: Although animal models suggest a beneficial effect of rifamycins in the reduction of inflammation during pneumococcal infections, 13 data in humans are not available. Therefore, we hypothesized that non-lytic rifampicin compared with lytic b-lactam antibiotic treatment would attenuate the inflammatory response in patients with pneumococcal pneumonia, shortly after the start of their treatment.
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