Selected article for: "emergency department and inflammatory response"
Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial
  • Document date: 2019_5_18
    • ID: 19ueli6e_58
    Snippet: Previous in vitro and animal studies have shown vast differences in LTA release and inflammatory response between lytic versus non-lytic antibiotic treatment. The potential clinical benefit of decreased LTA release and inflammatory response in patients with pneumococcal pneumonia might be substantial. Restrepo et al. 36 demonstrated that patients with community-acquired pneumonia who were immediately transferred to the ICU from the emergency depa.....
    Document: Previous in vitro and animal studies have shown vast differences in LTA release and inflammatory response between lytic versus non-lytic antibiotic treatment. The potential clinical benefit of decreased LTA release and inflammatory response in patients with pneumococcal pneumonia might be substantial. Restrepo et al. 36 demonstrated that patients with community-acquired pneumonia who were immediately transferred to the ICU from the emergency department were better off than patients who were initially treated on wards and thereafter transferred to the ICU. This secondary deterioration could be caused by inflammation due to LTA release after the start of treatment.

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