Author: Groeneveld, Geert H; van der Reyden, Tanny J; Joosten, Simone A; Bootsma, Hester J; Cobbaert, Christa M; de Vries, Jutte J C; Kuijper, Ed J; van Dissel, Jaap T
Title: Non-lytic antibiotic treatment in community-acquired pneumococcal pneumonia does not attenuate inflammation: the PRISTINE trial Document date: 2019_5_18
ID: 19ueli6e_7
Snippet: Patients were recruited at the emergency department. Inclusion criteria were: 18 years of age, hospital admission for community-acquired pneumonia and moderate to severe disease as defined by a confusion, uraemia, elevated respiratory rate, hypotension and aged 65 years or older (CURB-65) score 2, 16 or one or more of the risk factors for having pneumococcal pneumonia, i.e. pleuritic chest pain, acute onset of symptoms, cardiovascular disease, le.....
Document: Patients were recruited at the emergency department. Inclusion criteria were: 18 years of age, hospital admission for community-acquired pneumonia and moderate to severe disease as defined by a confusion, uraemia, elevated respiratory rate, hypotension and aged 65 years or older (CURB-65) score 2, 16 or one or more of the risk factors for having pneumococcal pneumonia, i.e. pleuritic chest pain, acute onset of symptoms, cardiovascular disease, leucocyte count .15%10e9/L and an alveolar pattern (lobar, segmental or sub-segmental infiltrate) on chest X-ray. 17 Exclusion criteria were: allergy to rifampicin, rifampicin-induced haemolytic anaemia or thrombocytopenia in medical history, liver failure, use of voriconazole or PIs, and pregnancy or breastfeeding.
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