Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use Document date: 2018_2_15
ID: 0emio4rl_32
Snippet: Clinical trials using PCT to guide antibiotic therapy for patients with acute respiratory tract infections have shown that a biomarker-driven algorithm can decrease antibiotic prescribing significantly and without an increase in adverse events or treatment failures [57] [58] [59] [60] [61] [62] . PCT-guided antibiotic stewardship reduced initial antibiotic prescription rates by 40% to 50% in patients with lower respiratory infection (LRI) present.....
Document: Clinical trials using PCT to guide antibiotic therapy for patients with acute respiratory tract infections have shown that a biomarker-driven algorithm can decrease antibiotic prescribing significantly and without an increase in adverse events or treatment failures [57] [58] [59] [60] [61] [62] . PCT-guided antibiotic stewardship reduced initial antibiotic prescription rates by 40% to 50% in patients with lower respiratory infection (LRI) presenting to the emergency departments [61] , 70% to 80% in ambulatory patients presenting to their general physicians [63] , and reduced total antibiotic exposure in community-acquired pneumonia by 40% to 50% [64] . In a single-center randomized controlled study, a significant reduction in antibiotic use in patients hospitalized with severe acute exacerbations of asthma was shown utilizing an algorithm of PCT measurements. In this study, withholding antibiotic treatment did not cause any apparent harm [65] .
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