Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use Document date: 2018_2_15
ID: 0emio4rl_41
Snippet: One approach to improve appropriate outpatient antibiotic use is to supplement the history and physical examination with point-of-care tests for selected biomarkers. Biomarkers such as CRP, PCT, and MxA respond differently to the host immune response and can help distinguish viral from a bacterial infection, including noninfectious causes of symptoms. At low levels, CRP and PCT are sensitive but not specific to bacterial infection, while at high .....
Document: One approach to improve appropriate outpatient antibiotic use is to supplement the history and physical examination with point-of-care tests for selected biomarkers. Biomarkers such as CRP, PCT, and MxA respond differently to the host immune response and can help distinguish viral from a bacterial infection, including noninfectious causes of symptoms. At low levels, CRP and PCT are sensitive but not specific to bacterial infection, while at high levels, both CRP and PCT become more specific to bacterial infection. Although PCT and CRP are not specific enough to differentiate a viral from bacterial infection, these biomarkers in combination with MxA substantially improve the differential diagnostic accuracy [7, 9, 24] . The combined interpretation of MxA with either CRP or PCT dramatically improves both sensitivity and specificity for differentiating a viral from bacterial infection [7, 8] .
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