Selected article for: "open reading frame and ORF open reading frame"
Author: Wang, Yuan; Li, Yan; Ding, Tianbing
Title: Heat shock protein 90ß in the Vero cell membrane binds Japanese encephalitis virus
  • Document date: 2017_6_26
    • ID: 7cpxg1b4_2
    Snippet: The JE causal agent, JEV, is a member of the genus Flavivirus, of the family Flaviviridae. The virion is spherical, small in size (40-60 nm) and contains an electron dense core ~30 nm in diameter that is surrounded by a lipid bilayer envelope. The viral genome is composed of a positive-sense, 10,976-nucleotide, single-stranded RNA, which features a methylated cap at the 5' end and does not contain a 3' poly (A) tail (11) . Flanked by hundreds of .....
    Document: The JE causal agent, JEV, is a member of the genus Flavivirus, of the family Flaviviridae. The virion is spherical, small in size (40-60 nm) and contains an electron dense core ~30 nm in diameter that is surrounded by a lipid bilayer envelope. The viral genome is composed of a positive-sense, 10,976-nucleotide, single-stranded RNA, which features a methylated cap at the 5' end and does not contain a 3' poly (A) tail (11) . Flanked by hundreds of nucleotides in non-coding regions (NCRs) on both termini, the viral RNA encodes a single long open reading frame (ORF) and translates into a large polyprotein precursor that is subsequently processed into structural (C, M and E) and non-structural (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) proteins by cellular and viral proteinases (12) .

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