Pathogen screening and prognostic factors in children with severe ARDS of pulmonary origin

Phung, Thuy Thi Bich; Suzuki, Tadaki; Phan, Phuc Huu; Kawachi, Shoji; Furuya, Hiroyuki; Do, Huong Thu; Kageyama, Tsutomu; Ta, Tuan Anh; Dao, Nam Huu; Nunoi, Hiroyuki; Tran, Dien Minh; Le, Hai Thanh; Nakajima, Noriko

The most frequently detected virus genome in TLF was AdV-B. In a previous study, we reported that children who died from measlesassociated pneumonia in our PICU during the same measles outbreak were complicated with ADV-B (type 7) pneumonia. 22 PICU-mortality was not associated with the type of causative pathogen, but rather with the inflammatory responses induced by host immunity. We evaluated the differences in serum levels of inflammatory mediators between non-survivors and survivors on the day of PICU admission and examined if they were associated with the type of infected pathogens. We found that the serum levels of IFN-γ were associated with fatal outcome (Fig. 1 and dengue patients. 37 IFN-γ has rarely been reported as a prognostic mediator for ARDS, but it was reported as one of the independent outcome predictors in H7N9-infected patients. 17 As shown in this study, particularly for children with severe ARDS of pulmonary origin with respiratory virus infection, we found that the serum level of IFN-γ was a possible prognostic factor of fatal outcome.