Author: Warnes, Sarah L.; Little, Zoë R.; Keevil, C. William
Title: Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials Document date: 2015_11_10
ID: 4d4l6mzl_11
Snippet: Copper ion release and generation of reactive oxygen species (ROS) are involved in inactivation of HuCoV-229E on copper and copper alloy surfaces. HuCoV-229E was inoculated onto copper and cartridge brass surfaces (100% and 70% copper, respectively; Table 1 ) in the presence of ethylenediaminetetraacetic acid (EDTA) and bathocuproine disulfonate (BCS), chelators of Cu(II) and Cu(I), respectively. Both chelators initially protected the virus from .....
Document: Copper ion release and generation of reactive oxygen species (ROS) are involved in inactivation of HuCoV-229E on copper and copper alloy surfaces. HuCoV-229E was inoculated onto copper and cartridge brass surfaces (100% and 70% copper, respectively; Table 1 ) in the presence of ethylenediaminetetraacetic acid (EDTA) and bathocuproine disulfonate (BCS), chelators of Cu(II) and Cu(I), respectively. Both chelators initially protected the virus from inactivation for up to 2 h (although BCS was still protective after 2 h of contact with brass) (Fig. 4A and C) . This suggests that both ionic species of copper are required directly and/or indirectly for virus inactivation and that Cu(I) may be more significant in the longer term.
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