Author: Xia, Shuai; Yan, Lei; Xu, Wei; Agrawal, Anurodh Shankar; Algaissi, Abdullah; Tseng, Chien-Te K.; Wang, Qian; Du, Lanying; Tan, Wenjie; Wilson, Ian A.; Jiang, Shibo; Yang, Bei; Lu, Lu
Title: A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike Document date: 2019_4_10
ID: 3c5ab73l_22
Snippet: On the basis of the distribution of EK1 by intranasal administration ( fig. S3, A and B) , we postulated that EK1 could penetrate the air-blood barrier to enter blood circulation and become enriched in some important organs, such as the liver and kidney. Therefore, we further examined levels of alanine aminotransferase (ALT; fig. S3F ) and creatinine ( fig. S3G ) in the sera of mice. ALT and creatinine showed no significant difference (P > 0.05) .....
Document: On the basis of the distribution of EK1 by intranasal administration ( fig. S3, A and B) , we postulated that EK1 could penetrate the air-blood barrier to enter blood circulation and become enriched in some important organs, such as the liver and kidney. Therefore, we further examined levels of alanine aminotransferase (ALT; fig. S3F ) and creatinine ( fig. S3G ) in the sera of mice. ALT and creatinine showed no significant difference (P > 0.05) at all time points between EK1-and PBS-treated groups, suggesting that nasal application of EK1 at high or low doses did not affect mouse hepatic and renal function.
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