Author: Li, Mao-Zhong; Zhang, Tie-Gang; Li, Ai-Hua; Luo, Ming; Jiao, Yang; Dong, Mei; Gong, Cheng; Huang, Fang
Title: A Pneumonia Case Associated with Type 2 Polio Vaccine Strains Document date: 2017_1_5
ID: 6hdk8801_6
Snippet: The results of the clinical and laboratory tests indicated that this pneumonia was caused by the polio virus. To the best of our knowledge, the relationship between the polio vaccine strain and pneumonia has not been previously reported. The polio vaccine strain can propagate and excrete in the upper respiratory system within several days after the OPV administration. In this case, it was unclear whether the polio vaccine strain was a provoking f.....
Document: The results of the clinical and laboratory tests indicated that this pneumonia was caused by the polio virus. To the best of our knowledge, the relationship between the polio vaccine strain and pneumonia has not been previously reported. The polio vaccine strain can propagate and excrete in the upper respiratory system within several days after the OPV administration. In this case, it was unclear whether the polio vaccine strain was a provoking factor or only a contributing factor to the pneumonia onset and development. The clinical and virologic investigation revealed that respiratory illnesses were diagnosed in many patients but only the Sabin poliovirus could be detected in their respiratory tracts, suggesting that ingested OPVs spread and cause diseases beyond the gastrointestinal tract. [3] The poliovirus caused outbreaks of human acute respiratory diseases or "minor illnesses" without clinical symptoms of the involvement of the central nervous system. A search of the database revealed that OPVs spread through the nasopharynx which is detected by serum neutralization from patients with acute respiratory infections. [5] Notably, an epidemiological investigation found that an infant had similar respiratory clinical symptoms after each dose of tOPV. Thus, these reports, along with the case in this study, support the causal relationship between the Type 2 polio vaccine and pneumonia.
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