Author: Ivanova, Elena; Berger, Audrey; Scherrer, Anne; Alkalaeva, Elena; Strub, Katharina
Title: Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits Document date: 2015_3_11
ID: 64cnoqpi_51
Snippet: We also incubated 43S complexes reconstituted from purified components with scAluY A RNP. We found 15% of SRP9/14 comigrating with the 43S complex ( Figure 5D , top panel). The amount of SRP9/14 bound to 40S was reduced ∼3-fold in the sample containing the inactive SA110 RNP ( Figure 5D, bottom panel) . The correlation between the ability of Alu RNPs to promote binding of h9/14 to the 40S subunit and the corresponding capacity to inhibit transl.....
Document: We also incubated 43S complexes reconstituted from purified components with scAluY A RNP. We found 15% of SRP9/14 comigrating with the 43S complex ( Figure 5D , top panel). The amount of SRP9/14 bound to 40S was reduced ∼3-fold in the sample containing the inactive SA110 RNP ( Figure 5D, bottom panel) . The correlation between the ability of Alu RNPs to promote binding of h9/14 to the 40S subunit and the corresponding capacity to inhibit translation initiation was fully consistent with the notion that the RNA component of the Alu RNP acted as an assembly factor to promote functional binding of SRP9/14 to 40S subunits.
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