Author: Lin, Tsai-Yu; Chin, Christopher R.; Everitt, Aaron R.; Clare, Simon; Perreira, Jill M.; Savidis, George; Aker, Aaron M.; John, Sinu P.; Sarlah, David; Carreira, Erick M.; Elledge, Stephen J.; Kellam, Paul; Brass, Abraham L.
Title: Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction Document date: 2013_11_21
ID: 10ynhrl3_21
Snippet: We began this study with the observation that treating cells with AmphoB prevented IFITM3-mediated restriction. Upon investigating this phenomenon, we found that overcoming IFITM3 is a principal component of AmphoB-enhanced IAV infection, both confirming and significantly extending a previous study reported during this investigation (Roethl et al., 2011) . Of consequence, we also showed that by neutralizing IFITM3's block to viral fusion, AmphoB .....
Document: We began this study with the observation that treating cells with AmphoB prevented IFITM3-mediated restriction. Upon investigating this phenomenon, we found that overcoming IFITM3 is a principal component of AmphoB-enhanced IAV infection, both confirming and significantly extending a previous study reported during this investigation (Roethl et al., 2011) . Of consequence, we also showed that by neutralizing IFITM3's block to viral fusion, AmphoB removed more than 60% of IFN's protective effects against IAV in vitro.
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