Immune complex glomerulonephritis of suspected iatrogenic origin in five Japanese Black calves

BERNIER GOSSELIN, Véronique; KIM, Dae Y.; NAGY, Dusty W.; SHOEMAKE, Brian M.; SHAW, Daniel P.; ROYAL, Angela B.; EVANS, Tim J.; MIDDLETON, John R.

Treatment was attempted at the VHC for 3 calves. Retrospectively, it is unknown if the antimicrobial and anti-inflammatory treatments were beneficial or needed. However, it is plausible that IV fluid therapy provided support of renal perfusion. It is unknown if any other treatment(s) could have improved the outcome. However, based on the hypothesis that the immune complexes were the result of the interaction of passively acquired antibodies and active immunization, it is postulated that the high morbidity could have been avoided by delaying vaccine administration until at least 21 days after administration of the hyperimmune serum. The label on the hyperimmune serum (Quatracon-2X; Boehringer Ingelhein Vetmedica) specifically cautions not to vaccinate with other viral and bacterial vaccines until 21 days after administration.