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Author: Jorge Blazquez-Prieto; Covadonga Huidobro; Ines Lopez-Alonso; Laura Amado-Rodriguez; Paula Martin-Vicente; Cecilia Lopez-Martinez; Irene Crespo; Cristina Pantoja; Pablo J Fernandez-Marcos; Manuel Serrano; Jacob I Sznajder; Guillermo M Albaiceta
Title: Cellular senescence limits acute lung injury induced by mechanical ventilation
  • Document date: 2020_3_25
    • ID: ebwxryai_37
    Snippet: Among the 55 genes of a previously identified transcriptomic senescence signature (13) , 44 were available in all the samples. A meta-score of expression of these 44 genes was computed for each sample and compared to assess the effect of lung injury and mechanical ventilation. Animals subjected to acid aspiration lung injury and mechanical ventilation showed higher meta-scores than spontaneously . CC-BY-NC-ND 4.0 International license author/fund.....
    Document: Among the 55 genes of a previously identified transcriptomic senescence signature (13) , 44 were available in all the samples. A meta-score of expression of these 44 genes was computed for each sample and compared to assess the effect of lung injury and mechanical ventilation. Animals subjected to acid aspiration lung injury and mechanical ventilation showed higher meta-scores than spontaneously . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.24.005983 doi: bioRxiv preprint breathing controls (ANOVA p-value<0.001, Figure 1B ). The expression of each gene of this signature is shown in Figure 1C . These results suggest that lung injury and mechanical ventilation activate the molecular mechanisms of senescence in acutely injured lungs.

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