Author: Darwish, Ilyse; Miller, Chris; Kain, Kevin C.; Liles, W. Conrad
Title: Inhaled Nitric Oxide Therapy Fails to Improve Outcome in Experimental Severe Influenza Document date: 2012_1_13
ID: 1rktb6yq_3
Snippet: In vitro, NO antimicrobial activity has been demonstrated against a variety of viruses including ectromilia virus, vaccinia virus, herpes simplex type 1 viruses, coronavirus, and influenza A and B viruses (18) (19) (20) (21) (22) . In these studies, administration of the NO donor S-nitroso-N-acetylpenicillamine (SNAP) to virus-infected cells significantly reduced viral burden. A human trial for treatment of severe acute respiratory syndrome (SARS.....
Document: In vitro, NO antimicrobial activity has been demonstrated against a variety of viruses including ectromilia virus, vaccinia virus, herpes simplex type 1 viruses, coronavirus, and influenza A and B viruses (18) (19) (20) (21) (22) . In these studies, administration of the NO donor S-nitroso-N-acetylpenicillamine (SNAP) to virus-infected cells significantly reduced viral burden. A human trial for treatment of severe acute respiratory syndrome (SARS) found inhaled NO (iNO), at 30 ppm or less, decreased the spread and intensity of lung infiltrates and improved arterial oxygen saturation (23) .
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