Author: Swatek, Kirby N.; Aumayr, Martina; Pruneda, Jonathan N.; Visser, Linda J.; Berryman, Stephen; Kueck, Anja F.; Geurink, Paul P.; Ovaa, Huib; van Kuppeveld, Frank J. M.; Tuthill, Tobias J.; Skern, Tim; Komander, David
Title: Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies Document date: 2018_3_6
ID: 3s86w4iw_3
Snippet: Among the 14 mature proteins encoded by FMDV are two peptidase activities required for self-processing and viral proliferation (4, 5) . The leader protease Lb pro is a papain-like cysteine protease that has several roles (4, 6) . First, Lb pro cleaves its own C terminus, releasing itself from the nascent polyprotein. Second, Lb pro also cleaves the two isoforms of eukaryotic initiation factor 4G (eIF4G), the inactivation of which diverts ribosome.....
Document: Among the 14 mature proteins encoded by FMDV are two peptidase activities required for self-processing and viral proliferation (4, 5) . The leader protease Lb pro is a papain-like cysteine protease that has several roles (4, 6) . First, Lb pro cleaves its own C terminus, releasing itself from the nascent polyprotein. Second, Lb pro also cleaves the two isoforms of eukaryotic initiation factor 4G (eIF4G), the inactivation of which diverts ribosomes to preferentially translate viral RNA via their internal ribosome entry site (4, 6) . Third, Lb pro was reported to subvert innate immune signaling pathways by acting as a deubiquitinase (DUB) (7) .
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