ISG20 promotes local tumor immunity and contributes to poor survival in human glioma

Gao, Mengqi; Lin, Yi; Liu, Xing; Li, Yiming; Zhang, Chuanbao; Wang, Zheng; Wang, Zhiliang; Wang, Yulin; Guo, Zongze

To better understand the mechanism of ISG20-promoted glioma progression, we determined the genes showing correlated expression with ISG20 among the whole transcriptome. Among the total 21,468 genes analyzed, 570 genes in the CGGA and 1925 genes in TCGA showed significant correlations with ISG20 expression (r > 0.5, Table S3 ). Subsequent pathway analyses showed that these genes were involved in a wide variety of immune responses, including innate immune response, T cell activation, inflammatory response, antigen processing and presentation, hematopoietic cell lineage, leukocyte migration, cytokine-cytokine receptor interaction, lysosome activation, and type I and II IFN signaling pathway (Figure 4; Fig. S3A ). ISG20 also appears to be involved in essential metabolic pathways, such as the regulation of protein processing and modification, proteasome synthesis, and galactose metabolism (data not shown). Collectively, these results indicated that ISG20 is highly involved with the immune response in the glioma microenvironment.