Selected article for: "respiratory syndrome and severe acute respiratory syndrome"
Author: Menachery, Vineet D.; Schäfer, Alexandra; Burnum-Johnson, Kristin E.; Mitchell, Hugh D.; Eisfeld, Amie J.; Walters, Kevin B.; Nicora, Carrie D.; Purvine, Samuel O.; Casey, Cameron P.; Monroe, Matthew E.; Weitz, Karl K.; Stratton, Kelly G.; Webb-Robertson, Bobbie-Jo M.; Gralinski, Lisa E.; Metz, Thomas O.; Smith, Richard D.; Waters, Katrina M.; Sims, Amy C.; Kawaoka, Yoshihiro; Baric, Ralph S.
Title: MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
  • Document date: 2018_1_30
    • ID: 096gtdy5_4
    Snippet: Vietnam/1203/2004 (H5N1; herein H5N1-VN1203), severe acute respiratory syndrome CoV (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) (6). Our results found that a subset of ISGs was down-regulated by both H5N1-VN1203 and MERS-CoV, despite intact host signaling and transcriptional factor activation. Importantly, repressive histone markers were associated with down-regulated genes and suggested that both MERS-CoV and H5N1-VN1203 use .....
    Document: Vietnam/1203/2004 (H5N1; herein H5N1-VN1203), severe acute respiratory syndrome CoV (SARS-CoV), and Middle East respiratory syndrome CoV (MERS-CoV) (6). Our results found that a subset of ISGs was down-regulated by both H5N1-VN1203 and MERS-CoV, despite intact host signaling and transcriptional factor activation. Importantly, repressive histone markers were associated with down-regulated genes and suggested that both MERS-CoV and H5N1-VN1203 use epigenetic modifications to modulate ISG stimulation. These results correspond with reports for other viruses and suggest epigenetics as a new horizon for viral antagonism (7, 8) .

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