Author: Lundegaard, Claus; Lund, Ole; Kesmir, Can; Brunak, Søren; Nielsen, Morten
Title: Modeling the adaptive immune system: predictions and simulations Document date: 2007_12_15
ID: 5m269nzi_3
Snippet: B-cell epitopes are normally classified into two groups: continuous and discontinuous epitopes. A continuous epitope, (also called a sequential or linear epitope) is a short peptide fragment in a protein that is recognized by antibodies specific for that protein. A discontinuous epitope is composed of residues that are not adjacent in the primary structure (amino acid sequence), but are brought into proximity by the folding of the polypeptide. Th.....
Document: B-cell epitopes are normally classified into two groups: continuous and discontinuous epitopes. A continuous epitope, (also called a sequential or linear epitope) is a short peptide fragment in a protein that is recognized by antibodies specific for that protein. A discontinuous epitope is composed of residues that are not adjacent in the primary structure (amino acid sequence), but are brought into proximity by the folding of the polypeptide. The classification is not clear-cut as discontinuous epitopes may contain linear stretches of amino acids, and continuous epitopes may show conformational preferences.
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