Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_23
Snippet: Older adjuvants continue to be explored to define those parameters critical for efficacy. Alum is one of the most commonly employed adjuvants because of its long history of use in humans and the relative ease for regulatory approval; for this reason, research to optimize its utility is ongoing. Hansen et al. [66 & ] showed that the ability of alum to adsorb an Env protein was important for immunogenicity, but that binding too tightly reduced immu.....
Document: Older adjuvants continue to be explored to define those parameters critical for efficacy. Alum is one of the most commonly employed adjuvants because of its long history of use in humans and the relative ease for regulatory approval; for this reason, research to optimize its utility is ongoing. Hansen et al. [66 & ] showed that the ability of alum to adsorb an Env protein was important for immunogenicity, but that binding too tightly reduced immune responses after immunization. Dorosko et al. showed that alternative methods of delivering alum can direct the immune response; injection of an alum-based peptide immunogen in the region of the supramammary lymph node of goats resulted in antibody secretion into colostrum [67] .
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