Author: Moody, M. Anthony
Title: Modulation of HIV-1 immunity by adjuvants Document date: 2014_4_10
ID: 1nm1tbig_29
Snippet: For eliciting mucosal responses, cholera toxin (CT) and other bacterial products have been extensively tested in animal models. CT combined with Env gp120 elicited mucosal IgA in rhesus macaques [81] ; other studies in rhesus (albeit with a different form of CT) have elicited more mixed responses [82] . CT has also been used to direct responses to the mucosa by combining it with agents that enhance retention at the mucosal surface, and has permit.....
Document: For eliciting mucosal responses, cholera toxin (CT) and other bacterial products have been extensively tested in animal models. CT combined with Env gp120 elicited mucosal IgA in rhesus macaques [81] ; other studies in rhesus (albeit with a different form of CT) have elicited more mixed responses [82] . CT has also been used to direct responses to the mucosa by combining it with agents that enhance retention at the mucosal surface, and has permitted dose sparing [83] . In addition, modified CT combined with cytokines were able to elicit mucosal antibodies to a peptide immunogen when given to cynomolgus monkeys [84] , suggesting that promising combinations identified by other vaccine strategies (e.g., DNA vaccination) might be useful for mucosal immunization.
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