Author: Lulin Huang; Yi Shi; Bo Gong; Li Jiang; Xiaoqi Liu; Jialiang Yang; Juan Tang; Chunfang You; Qi Jiang; Bo Long; Tao Zeng; Mei Luo; Fanwei Zeng; Fanxin Zeng; Shuqiang Wang; Xingxiang Yang; Zhenglin Yang
Title: Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19 Document date: 2020_3_17
ID: 2okcuviq_25
Snippet: In conclusion, in this study, we revealed the immune response process of SARS-CoV-2 entering the blood circulation system using immune profiling analysis with single-cell resolution. In the critical condition, the number of different cell types, expressed genes, and TCR/BCR responses indicated a relationship between the critical nature of the patient's condition and his immunodeficiency. On the contrary, the severe condition was shown to be relat.....
Document: In conclusion, in this study, we revealed the immune response process of SARS-CoV-2 entering the blood circulation system using immune profiling analysis with single-cell resolution. In the critical condition, the number of different cell types, expressed genes, and TCR/BCR responses indicated a relationship between the critical nature of the patient's condition and his immunodeficiency. On the contrary, the severe condition was shown to be related to a strong autoimmune response and over-activated interferon pathway. These results suggested that immune deficiency or immune over-reacts may make patients with COVID-19 go to worse condition because of their imbalance adaptive immune response (33) (34) (35) . Our study also shows that the activation of the interferon-MAPK signaling pathway and TCR-and BCRproduced antibodies play key roles in combating SARS-CoV-2 infection. These results will provide important information for COVID-19 treatment and drug development.
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