Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19

Lulin Huang; Yi Shi; Bo Gong; Li Jiang; Xiaoqi Liu; Jialiang Yang; Juan Tang; Chunfang You; Qi Jiang; Bo Long; Tao Zeng; Mei Luo; Fanwei Zeng; Fanxin Zeng; Shuqiang Wang; Xingxiang Yang; Zhenglin Yang

The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03. 15.20033472 doi: medRxiv preprint FOS is up-regulated in hospitalized patients but down-regulated in cured patients. (B) Immunofluorescence staining of IFI27 in PBMCs of patients with COVID-19 and normal controls. (C) Anti-SARS-CoV-2 response of the blood system. After the virus reaches the blood immune cells, it can activate multiple cell subtypes of the interferon signal pathway to produce effectors, such as IFI27, IFITM1, and IFITM3, to fight the virus. Through downstream activation of MAPK, the expression of downstream effectors is activated by key transcription factors, FOS, JUN, and JUNB, which lead to a wide range of antiviral responses in the blood system. All rights reserved. No reuse allowed without permission. the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.