Phenol-Rich Compounds Sweet Gel: A Statistically More Effective Antibiotic than Cloxacillin Against Pseudomonas Aeruginosa

Dashtdar, Mehrab; Dashtdar, Mohammad Reza; Dashtdar, Babak; Khan, Gazala Afreen; Kardi, Karima

Biofilm formation seems to facilitate the survival of P. aeruginosa in the environment and in their hosts. Bacterial biofilms are structured masses of bacterial cells coated with a hydrated polymeric matrix of their own synthesis. The biofilm protects the bacteria and allows them to survive in hostile environmental conditions. The biofilm bacteria can withstand the immune response of the host and are much more resistant to antibiotics and disinfectants than planktonic bacterial cells. The ability to form a biofilm is now recognized as a characteristic of many microorganisms [7] [8] [9] . The presence of biofilms during infections therefore requires new methods of prevention, diagnosis and treatment. The existence of biofilms and antibiotic resistance has emerged as one of the greatest threats to global health and, brings an additional level of complexity to the control of chronic ulcers. The "black beast" of burn centers, Pseudomonas, is responsible for 10% of bloodstream infections and 28% of deaths. Therefore, alternative antimicrobial strategies are urgently needed, and this situation has led to a re-evaluation of the therapeutic use of ancient remedies, such as herbal extracts and herbal-based products.