Phenol-Rich Compounds Sweet Gel: A Statistically More Effective Antibiotic than Cloxacillin Against Pseudomonas Aeruginosa

Dashtdar, Mehrab; Dashtdar, Mohammad Reza; Dashtdar, Babak; Khan, Gazala Afreen; Kardi, Karima

Several studies that have been conducted in recent years have manifested the antibiotic activities of some phenol compounds in natural plants extracts, including Acacia catechu (L.F.) Willd, Castanea sativa, Momia (Shilajit) and Ephedra sinica stapf [15] . Honey, maple saps, Phoenix dactylifera L. (dates) extract and pomegranate which are well known for their high levels of antioxidants and polyphenols have also shown promise as novel antimicrobial agents. Phenol compounds have recently attracted much interest due to their antioxidants properties and their potential beneficial implications for human health, such as their use in the treatment and the prevention of cancer, cardiovascular diseases and inflammatory diseases. The effectiveness of these above substances; has been demonstrated in several studies [16] [17] [18] [19] . However, no effort has been made to evaluate the synergic effects of combined natural sweeteners on enhancing the antibiotic activities of natural plants extracts. The topical formulations that on certain vitamins and nutrients, are rich in phenol compounds, and are applied directly to wounds are more effective for reducing the risk of infection and for stimulating healing. Meanwhile, phenol-rich compounds; provides a number of essential minerals such as zinc, potassium, iron, magnesium and calcium (Table 1 ). In order to obtain a natural antibiotic for the dressing and the treatment of chronic wounds, we conducted this study to find an innovative strategy for using natural medicine derived from phenol-rich compounds that have been tested on bacterial strains of a reference such P. aeruginosa.