2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

14.4 ml of blood caused profound hypertensive hydrocephalus in the terminal procedures but the first survival pig could not be recovered from anesthesia. Using 10 ml of blood, hypertensive hydrocephalus occurred in 12 of 13 pigs. In one pig, the subarachnoid space was inadvertently injected and hydrocephalus did not Fenbendazole produces these effects at a mean inhibitory concentration (IC 50 ) of 150 ng/ml, which might be an initial target for therapeutic CSF concentrations. Our study aimed to describe the time course of fenbendazole in plasma and CSF after oral administration to dogs. Doses were designed to target a CSF concentration approaching 150 ng/ml. Fenbendazole was detected in canine plasma and CSF using high performance liquid chromatography; the limit of detection was 10 ng/ml and 5 ng/ml, respectively.