Title: 2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018 Document date: 2018_10_25
ID: 60ceejq1_288
Snippet: These results call in to question the generally accepted hypothesis that glycosuria-induced osmotic diuresis is the primary cause of polyuria in diabetes mellitus. Of note, in adulthood in both species, the expression of PAX4 has been shown to contribute to reprogramming of exocrine cells and α-cells into insulin-producing β-cells; induction of ARX expression in β-cells leads them to reprogramming into α-cells. We recently discovered that dia.....
Document: These results call in to question the generally accepted hypothesis that glycosuria-induced osmotic diuresis is the primary cause of polyuria in diabetes mellitus. Of note, in adulthood in both species, the expression of PAX4 has been shown to contribute to reprogramming of exocrine cells and α-cells into insulin-producing β-cells; induction of ARX expression in β-cells leads them to reprogramming into α-cells. We recently discovered that diabetic cats have an increased number of cells in the exocrine pancreas that stain positive for a marker of proliferation (proliferating cell nuclear antigen; PCNA), in particular nearby islets.
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