2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

In summary, the upregulation of IL-10 was significantly correlated with the distribution of Tregs in polypoid lesions of ICRP-affected MDs. However, the rate of increase in the expression level of IL-10 was relatively low compared to that of proinflammatory and Th17 cytokines. Therefore, the increase in numbers of Tregs and antiinflammatory cytokines in polypoid lesions was considered to be a reactive change and was insufficient to regulate the development of inflammation. Further analysis on the association between Treg distribution in the lesion and the prognosis, including the response to immunosuppressive therapy, are warranted.No The affected dogs were housed in a single shelter and the design was approved by the shelter and by the Clinical Review Board. A fecal score was determined by 1 of 4 trained observers that was masked to the diet groups on each sample by comparing to a standardized score sheet: 0 = no stool; 1 = very hard and dry; 2 = firm but not hard; 3 = normal, little or no segmentation, moist; 4 = very moist, log shaped; 5 = very moist, piles; 6 = texture but no defined shape; and 7 = watery puddle. To qualify for the study, each dog had to present with a fecal score > 4 and have hematochezia, mucus, or straining. The dogs were randomized to be fed 1 of the 2 diets and all were administered fenbendazole at 50 mg/kg, PO, daily for 5 days and metronidazole at 10 -15 mg/kg, PO, twice daily for 5 days. A dog had to be in the study for at least 4 days to be included in the data analysis. The proportions of dogs with a fecal score of less than 5 on the day of adoption or the last study day (Day 9) and the proportions of stools in each group with a fecal score of greater than 3 were compared by Fisher's exact test with significance defined as P < 0.05.