2018 ACVIM Forum Research Abstract Program: Seattle, Washington, June 14 - 15, 2018

Fourteen healthy client-owned dogs were evaluated using a randomized placebo cross-over study in a pairwise fashion, each dog receiving treatment every 12 hours for a two-week period. An approximate 12-hour voided urine sample was collected at the end of each treatment period. Samples were analyzed for pH, sodium, potassium, chloride, calcium, phosphorous, magnesium, citrate, oxalate, ammonia, and creatinine. Relative supersaturation for calcium oxalate and struvite was estimated using an iterative computer program (EQUIL 93b, University of Florida, Gainesville, FL). Data were assessed for normal distribution using Shapiro-Wilk. Paired t-test (normal distribution) or Wilcoxon signed rank (non-normal distribution) were used for statistical analysis. Data were analyzed using 2-tailed statistical testing except for relative supersaturation and urine volume where 1-tailed testing was used. A p-value < 0.05 was considered significant.