Selected article for: "chain reaction and respiratory illness"
Author: Lambert, Stephen Bernard; Ware, Robert S; Cook, Anne L; Maguire, Frances A; Whiley, David M; Bialasiewicz, Seweryn; Mackay, Ian M; Wang, David; Sloots, Theo P; Nissen, Michael D; Grimwood, Keith
Title: Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
  • Document date: 2012_10_31
    • ID: 06e9lkwl_3
    Snippet: The Observational Research in Childhood Infectious Diseases (ORChID) study is an ongoing study enrolling a dynamic birth cohort to document the community-based epidemiology of viral respiratory and gastrointestinal infections in early childhood. Women are recruited antenatally, and their healthy newborn is followed for the first two years of life. Parents keep a daily symptom diary for the study child, collect a weekly anterior nose swab and dirt.....
    Document: The Observational Research in Childhood Infectious Diseases (ORChID) study is an ongoing study enrolling a dynamic birth cohort to document the community-based epidemiology of viral respiratory and gastrointestinal infections in early childhood. Women are recruited antenatally, and their healthy newborn is followed for the first two years of life. Parents keep a daily symptom diary for the study child, collect a weekly anterior nose swab and dirty nappy swab, and complete a burden diary when a child meets pre-defined illness criteria. Specimens will be tested for a wide range of viruses by real-time polymerase chain reaction assays. Primary analyses will involve calculating incidence rates for acute respiratory illness (ARI) and acute gastroenteritis (AGE) for the cohort by age and seasonality. Control material from children when they are without symptoms will allow us to determine what proportion of ARIs and AGE can be attributed to specific pathogens. Secondary analyses will assess the incidence and shedding duration of specific respiratory and gastrointestinal pathogens.

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