Author: Chunlong Ma; Brett Hurst; Yanmei Hu; Tommy Szeto; Bart Tarbet; Jun Wang
Title: Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease Document date: 2020_4_20
ID: 047xpt2c_14
Snippet: To test the hypothesis that inhibiting the enzymatic activity of M pro will lead to the inhibition of SARS-CoV-2 viral replication, we performed cellular antiviral assays for the five promising hits 64, 28, 43, 61, and 62 against SARS-CoV-2. For this, we first tested the cellular cytotoxicity of these compounds in multiple cell lines (Table 3) . GC-376 (64), boceprevir (28) , and calpain inhibitor II (61) were well tolerated and had CC50 values o.....
Document: To test the hypothesis that inhibiting the enzymatic activity of M pro will lead to the inhibition of SARS-CoV-2 viral replication, we performed cellular antiviral assays for the five promising hits 64, 28, 43, 61, and 62 against SARS-CoV-2. For this, we first tested the cellular cytotoxicity of these compounds in multiple cell lines (Table 3) . GC-376 (64), boceprevir (28) , and calpain inhibitor II (61) were well tolerated and had CC50 values of over 100 µM for all the cell lines tested.
Search related documents:
Co phrase search for related documents- antiviral assay and cellular antiviral assay: 1, 2, 3, 4, 5, 6, 7, 8, 9
- antiviral assay and cellular cytotoxicity: 1, 2
- antiviral assay and enzymatic activity: 1, 2
- antiviral assay and SARS viral replication: 1, 2, 3, 4, 5
- antiviral assay and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cell line and enzymatic activity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cell line and multiple cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- cell line and SARS viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9
- cell line and SARS viral replication inhibition: 1
- cell line and test cell line: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- cell line and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cellular antiviral assay and enzymatic activity: 1
- cellular antiviral assay and viral replication: 1, 2, 3
- cellular cytotoxicity and viral replication: 1, 2, 3, 4, 5
- enzymatic activity and SARS viral replication: 1, 2, 3, 4, 5, 6, 7
- enzymatic activity and SARS viral replication inhibition: 1
- enzymatic activity and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- multiple cell line and viral replication: 1
- promising hit and SARS viral replication: 1, 2
Co phrase search for related documents, hyperlinks ordered by date