Author: Mitsakakis, Konstantinos; Kaman, Wendy E; Elshout, Gijs; Specht, Mara; Hays, John P
Title: Challenges in identifying antibiotic resistance targets for point-of-care diagnostics in general practice Document date: 2018_8_16
ID: 44ychud2_8
Snippet: Be aware of potential limitations associated with the molecular detection of antibiotic resistance genes. Gene promoter and coding region sequencing may provide some idea of the expression of specific antibiotic resistance genes, but mRNA or protein-based diagnostics may be required. Note that even mRNA and protein may not detect 'dormant' antibiotic resistance genes that have not yet been exposed to antibiotics.....
Document: Be aware of potential limitations associated with the molecular detection of antibiotic resistance genes. Gene promoter and coding region sequencing may provide some idea of the expression of specific antibiotic resistance genes, but mRNA or protein-based diagnostics may be required. Note that even mRNA and protein may not detect 'dormant' antibiotic resistance genes that have not yet been exposed to antibiotics
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