Selected article for: "peripheral blood and protein expression"
Author: Joseph, Patrick; Godofsky, Eliot
Title: Outpatient Antibiotic Stewardship: A Growing Frontier—Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve Antibiotic Use
  • Document date: 2018_2_15
    • ID: 0emio4rl_17
    Snippet: In most cases of acute viral infections, type I IFN and MxA are released into the peripheral blood. Detection of interferons in serum is difficult and unreliable, mainly due to their short half-life [30] . In contrast, MxA has a long half-life of 2.3 days, low baseline level of less than 15 ng/mL, and a fast induction time of 1-2 hours after infection [32] . The low basal levels of MxA protein in tissues, its exclusive expression by type I IFNs, .....
    Document: In most cases of acute viral infections, type I IFN and MxA are released into the peripheral blood. Detection of interferons in serum is difficult and unreliable, mainly due to their short half-life [30] . In contrast, MxA has a long half-life of 2.3 days, low baseline level of less than 15 ng/mL, and a fast induction time of 1-2 hours after infection [32] . The low basal levels of MxA protein in tissues, its exclusive expression by type I IFNs, and its relatively long half-life make it an excellent biomarker for systemic IFN-α/β production in viral infections.

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