Selected article for: "assemble contig and contig assemble"
Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design
  • Document date: 2018_3_12
    • ID: a9lkhayg_14
    Snippet: Next we analyzed how capture improved our ability to assemble viral genomes. For samples that had partial genome assemblies (< 90%) before capture, we found that application of V ALL allowed us to assemble a greater fraction of the genome in all cases (Fig. 2c) . Importantly, of the 14 samples from which we were unable to assemble any contig before capture, 11 assembled at least partial genomes (> 50%) using V ALL , of which 4 were complete genom.....
    Document: Next we analyzed how capture improved our ability to assemble viral genomes. For samples that had partial genome assemblies (< 90%) before capture, we found that application of V ALL allowed us to assemble a greater fraction of the genome in all cases (Fig. 2c) . Importantly, of the 14 samples from which we were unable to assemble any contig before capture, 11 assembled at least partial genomes (> 50%) using V ALL , of which 4 were complete genomes (> 90%). Many of the viruses we tested, such as HCV and HIV-1, are known to have high within-species diversity yet the enrichment of their unique content was consistent with that of less diverse species (Supplementary Table 3 ).

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