Selected article for: "Supplementary Table and viral content"
Author: Hayden C. Metsky; Katherine J. Siddle; Adrianne Gladden-Young; James Qu; David K. Yang; Patrick Brehio; Andrew Goldfarb; Anne Piantadosi; Shirlee Wohl; Amber Carter; Aaron E. Lin; Kayla G. Barnes; Damien C. Tully; Björn Corleis; Scott Hennigan; Giselle Barbosa-Lima; Yasmine R. Vieira; Lauren M. Paul; Amanda L. Tan; Kimberly F. Garcia; Leda A. Parham; Ikponmwonsa Odia; Philomena Eromon; Onikepe A. Folarin; Augustine Goba; Etienne Simon-Lorière; Lisa Hensley; Angel Balmaseda; Eva Harris; Douglas Kwon; Todd M. Allen; Jonathan A. Runstadler; Sandra Smole; Fernando A. Bozza; Thiago M. L. Souza; Sharon Isern; Scott F. Michael; Ivette Lorenzana; Lee Gehrke; Irene Bosch; Gregory Ebel; Donald Grant; Christian Happi; Daniel J. Park; Andreas Gnirke; Pardis C. Sabeti; Christian B. Matranga
Title: Capturing diverse microbial sequence with comprehensive and scalable probe design
  • Document date: 2018_3_12
    • ID: a9lkhayg_20
    Snippet: We next compared the V ALL probe set to the two 2-virus probe sets V MM and V ZC . We found that enrichment for MuV and ZIKV samples was slightly higher using the 2-virus probe sets than with V ALL (2.26× more unique viral reads; Q 1 = 1.69, Q 3 = 3.36) (Supplementary Table 3 , Supplementary Fig. 4 , Supplementary Fig. 8c, d) . The additional gain of these probe sets might be useful in some applications, but was considerably less than the 18× i.....
    Document: We next compared the V ALL probe set to the two 2-virus probe sets V MM and V ZC . We found that enrichment for MuV and ZIKV samples was slightly higher using the 2-virus probe sets than with V ALL (2.26× more unique viral reads; Q 1 = 1.69, Q 3 = 3.36) (Supplementary Table 3 , Supplementary Fig. 4 , Supplementary Fig. 8c, d) . The additional gain of these probe sets might be useful in some applications, but was considerably less than the 18× increase provided by V ALL against a pre-capture sample. Overall, our results suggest that neither the complexity of the V ALL probe set nor its use of shorter ssDNA probes prevent it from efficiently enriching viral content.

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